Publications and Collaborations

Role of the Nitro Functionality in the DNA Binding of 3-Nitro-10-methylbenzothiazolo[3,2-a] quinolinium Chloride
Iris Gisela Colón, Fernando A. Gonzalez, Marisol Cordero, Beatriz Zayas, Christian Veléz, Osvaldo Cox, Ajay Kumar, and Antonio E. Alegría. Chemical Research Toxicology. 2008; 21, 1706-1715.
Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation. 

Alegria AE, Sanchez-Cruz P, Kumar A, Garcia C, Gonzalez FA, Orellano A, Zayas B, Gordaliza M. Free Radic Res. 2008 Jan;42(1):70-81.
Comparison of the nucleic acid covalent binding capacity of two nitro substituted benzazolo [3,2-a]quinolinium salts upon enzymatic reduction. 

Zayas B, Beyley J, Terron M, Cordero M, Hernandez W, Alegría AE, Cox O. Toxicology In vitro 2007 Sep;21(6):1155-64 Epub 2007 Mar 13.
Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients. 

Zayas B, Stillwell SW, Wishnok JS, Trudel LJ, Skipper P, Yu MC, Tannenbaum SR, Wogan GN. Carcinogenesis. 2007 Feb;28(2):342-9. Epub 2006 Aug 21.
DNA adducts formed by a novel antitumor agent 11beta-dichloro in vitro and in vivo. 

Hillier SM, MarquisJC, Zayas B, Wishnok JS, Liberman RG, Skipper PL, Tannenbaum SR, EssigmannJM, Croy RG. Mol Cancer Ther. 2006 Apr;5(4): 977-84.
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells. 

Mitra K, Marquis JC, Hillier SM, Rye PT, Zayas B, Lee AS, Essigmann JM, Croy RG. J Am Chem Soc. 2002 Mar6; 124(9): 1862-3.

We are at the present working with the collaboration of:

Rosa-Molinar Laboratory (Biological Imaging Group) University of Puerto Rico – Río Piedras Campus. (

Antonio Alegria's Laboratory University of Puerto Rico- Humacao Campus.


ABQ 38 with Hoechst 60x.

ABQ 38 with Hoechst 60x.
Biological Imaging Group

ABQ 95 Exposure 60x.

ABQ 95 Exposure 60x.
Biological Imaging Group