Publications and Collaborations

Role of the Nitro Functionality in the DNA Binding of 3-Nitro-10-methylbenzothiazolo[3,2-a] quinolinium Chloride
Iris Gisela Colón, Fernando A. Gonzalez, Marisol Cordero, Beatriz Zayas, Christian Veléz, Osvaldo Cox, Ajay Kumar, and Antonio E. Alegría. Chemical Research Toxicology. 2008; 21, 1706-1715.
Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation. 
Alegria AE, Sanchez-Cruz P, Kumar A, Garcia C, Gonzalez FA, Orellano A, Zayas B, Gordaliza M. Free Radic Res. 2008 Jan;42(1):70-81.
Comparison of the nucleic acid covalent binding capacity of two nitro substituted benzazolo [3,2-a]quinolinium salts upon enzymatic reduction. 
Zayas B, Beyley J, Terron M, Cordero M, Hernandez W, Alegría AE, Cox O. Toxicology In vitro 2007 Sep;21(6):1155-64 Epub 2007 Mar 13.
Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients. 
Zayas B, Stillwell SW, Wishnok JS, Trudel LJ, Skipper P, Yu MC, Tannenbaum SR, Wogan GN. Carcinogenesis. 2007 Feb;28(2):342-9. Epub 2006 Aug 21.
DNA adducts formed by a novel antitumor agent 11beta-dichloro in vitro and in vivo. 
Hillier SM, MarquisJC, Zayas B, Wishnok JS, Liberman RG, Skipper PL, Tannenbaum SR, EssigmannJM, Croy RG. Mol Cancer Ther. 2006 Apr;5(4): 977-84.
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells. 
Mitra K, Marquis JC, Hillier SM, Rye PT, Zayas B, Lee AS, Essigmann JM, Croy RG. J Am Chem Soc. 2002 Mar6; 124(9): 1862-3.


We are at the present working with the collaboration of:

Rosa-Molinar Laboratory (Biological Imaging Group) University of Puerto Rico – Río Piedras Campus. ( http://pisces.cnnet.clu.edu/erm-lab/)

Antonio Alegria's Laboratory University of Puerto Rico- Humacao Campus.

IMPORTANT RELATED INSTITUTIONs:

• National Institute of Environmental Health Sciences. (http://www.niehs.nih.gov/)
• National Institutes of Health. (http://www.nih.gov/)
• UMET School of Environmental Affairs  (http://www.suagm.edu/umet/oa_pe_asuntos_ambientales.asp?cn_id=639) 
• Universidad Metropolitana (http://www.suagm.edu/suagm/umet/default.aspx)
• ChEMTox Laboratory (http://www.suagm.edu/umet/en/oa_pe_aa_chemtox_laboratory_message.asp)
• Alliance for the Advancement of Biomedical Research Excellence in Puerto Rico (AABRE) (http://aabre.hpcf.upr.edu/abesi---background.html)